ea0038p199 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015
Martinez de la Escalera Lucia
, Jackisch Laura
, Kyrou Ioannis
, Vrbikova Jana
, Hainer Vojtech
, Fried Martin
, Sramkova Petra
, Piya Milan
, Kumar Sudhesh
, Tripathi Gyanendra
, McTernan Philip
Aims/hypothesis: Genetic and functional defects in mitochondria are linked with phenotypes of obesity, hypercholesterolemia, and type 2 diabetes (T2DM). However, the impact on mitochondria during surgery-induced metabolic recovery is unknown. We therefore studied the effect of restrictive versus malabsorptive bariatric procedures on indicators of mitochondrial efficiency and control of biogenesis/function.Methods: Forty-three morbidly obese, T2DM consent...